Role of PGE₂ in colonic motility: PGE₂ attenuates spontaneous contractions of circular smooth muscle via EP₄ receptors in the rat colon.

ABSTRACT: Colonic motor activity is important for the formation and propulsion of feces. The production of prostaglandins (PGs) in colonic tissue is considered to play a critical role in the generation and regulation of colonic motility. In this study, we investigated the inhibitory effects of PGE₂ and selective agonists of four EP receptors on the spontaneous phasic contractions, called 'giant contractions' (GCs), of mucosa-free circular smooth muscle strips from the rat middle colon. Neural blockade with tetrodotoxin (TTX) increased the frequency and amplitude of the GCs by about twofold. However, inhibiting PG production with piroxicam reduced the GC frequency in the presence of TTX, but did not affect the GC amplitude. In the presence of both TTX and piroxicam, exogenous PGE₂

SUBMITTER: Karaki SI 

PROVIDER: S-EPMC10717948 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature