Single-nucleus transcriptome sequencing reveals hepatic cell atlas in pigs.

ABSTRACT:

Background

As the largest substantive organ of animals, the liver plays an essential role in the physiological processes of digestive metabolism and immune defense. However, the cellular composition of the pig liver remains poorly understood. This investigation used single-nucleus RNA sequencing technology to identify cell types from liver tissues of pigs, providing a theoretical basis for further investigating liver cell types in pigs.

Results

The analysis revealed 13 cells clusters which were further identified 7 cell types including endothelial cells, T cells, hepatocytes, Kupffer cells, stellate cells, B cells, and cholangiocytes. The dominant cell types were endothelial cells, T cells and hepatocytes in the liver tissue of Dahe pigs and Dahe black pigs, which accounts f

SUBMITTER: Zhu JH 

PROVIDER: S-EPMC10717992 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature