Remarkable effects of infliximab on severe radiation-induced side effects in a patient with uterine cervical cancer: a case report.

ABSTRACT: Pelvic radiotherapy is a powerful treatment for a broad range of cancers, including gynecological, prostate, rectal, and anal cancers. Despite improvements in the delivery of ionizing beams, damage to non-cancerous tissue can cause long-term effects that are potentially severe, affecting quality of life and daily function. There is an urgent need for new strategies to treat and reverse the side effects of pelvic radiotherapy without compromising the antitumor effect. A woman with severe radiation-induced intestinal side effects was treated with the tumor necrosis factor-alpha inhibitor infliximab with a dose of 3 mg/kg every 4 to 6 weeks. With infliximab treatment, a remarkable improvement in her bowel health was observed. The patient's late bowel toxicity was reduced from Grade 2 to Grade

SUBMITTER: Toft Moren A 

PROVIDER: S-EPMC10718054 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature