Critical assessment of selenourea as an efficient small molecule fluorescence quenching probe to monitor protein dynamics.

ABSTRACT: Organoselenium compounds have recently been the experimentalists' delight due to their broad applications in organic synthesis, medicinal chemistry, and materials science. Selenium atom replacement of the carbonyl oxygen of the urea moiety dramatically reduces the HOMO-LUMO gap and oxidation potential, which completely changes the physicochemical properties of selenocarbonyl compounds. To our surprise, the photophysics and utility of a simple molecule such as selenourea (SeU) have not been explored in detail, which persuaded us to investigate its role in excited state processes. The steady-state emission, temperature-dependent time-correlated single photon counting, and femtosecond fluorescence upconversion experimental results confirmed that SeU significantly enhances the fluorescence que

SUBMITTER: Jena S 

PROVIDER: S-EPMC10718066 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature