Total Synthesis of Sanctolide A and Formal Synthesis of (2S)-Sanctolide A.

ABSTRACT: Two synthetic strategies employing phosphate tether-mediated one-pot sequential protocols for the total synthesis of the polyketide nonribosomal peptide macrolide, sanctolide A, and the formal synthesis of the (2S)-epimer of sanctolide A are reported. In this work, a phosphate tether-mediated one-pot sequential ring-closing metathesis/cross metathesis/substrate-controlled "H₂"/tether removal approach was developed to accomplish the total synthesis of the natural product sanctolide A.

SUBMITTER: Dissanayake GC 

PROVIDER: S-EPMC10718183 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature