Trends in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and vaccine antibody prevalence in a multi-ethnic inner-city antenatal population: A cross-sectional surveillance study.

ABSTRACT:

Objective

To determine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence in pregnancy in an inner-city setting and assess associations with demographic factors and vaccination timing.

Design

Repeated cross-sectional surveillance study.

Setting

London maternity centre.

Sample

A total of 906 pregnant women attending nuchal scans, July 2020-January 2022.

Methods

Blood samples were tested for IgG antibodies against SARS-CoV-2 nucleocapsid (N) and spike (S) proteins. Self-reported vaccination status and coronavirus disease 2019 (COVID-19) infection were recorded. Multivariable regression models determined demographic factors associated with seroprevalence and antibody titres.

Main outcome measures

Immunoglobulin G N- and S-pro

SUBMITTER: Andreeva D 

PROVIDER: S-EPMC10718194 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature