Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice.

ABSTRACT:

Background aims

Human genetic variation is thought to guide the outcome of HCV infection, but model systems within which to dissect these host genetic mechanisms are limited. Norway rat hepacivirus, closely related to HCV, causes chronic liver infection in rats but causes acute self-limiting hepatitis in typical strains of laboratory mice, which resolves in 2 weeks. The Collaborative Cross (CC) is a robust mouse genetics resource comprised of a panel of recombinant inbred strains, which model the complexity of the human genome and provide a system within which to understand diseases driven by complex allelic variation.

Approach results

We infected a panel of CC strains with Norway rat hepacivirus and identified several that failed to clear the virus after 4 weeks. Strains di

SUBMITTER: Brown AJ 

PROVIDER: S-EPMC10718216 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature