LIM domain only 7 negatively controls nonalcoholic steatohepatitis in the setting of hyperlipidemia.

ABSTRACT:

Background and aims

Hyperlipidemia has been extensively recognized as a high-risk factor for NASH; however, clinical susceptibility to NASH is highly heterogeneous. The key controller(s) of NASH susceptibility in patients with hyperlipidemia has not yet been elucidated. Here, we aimed to reveal the key regulators of NASH in patients with hyperlipidemia and to explore its role and underlying mechanisms.

Approach and results

To identify the predominant suppressors of NASH in the setting of hyperlipidemia, we collected liver biopsy samples from patients with hyperlipidemia, with or without NASH, and performed RNA-sequencing analysis. Notably, decreased Lineage specific Interacting Motif domain only 7 (LMO7) expression robustly correlated with the occurrence and severity of NASH

SUBMITTER: Wu T 

PROVIDER: S-EPMC10718224 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature