FiMAP: A fast identity-by-descent mapping test for biobank-scale cohorts.

ABSTRACT: Although genome-wide association studies (GWAS) have identified tens of thousands of genetic loci, the genetic architecture is still not fully understood for many complex traits. Most GWAS and sequencing association studies have focused on single nucleotide polymorphisms or copy number variations, including common and rare genetic variants. However, phased haplotype information is often ignored in GWAS or variant set tests for rare variants. Here we leverage the identity-by-descent (IBD) segments inferred from a random projection-based IBD detection algorithm in the mapping of genetic associations with complex traits, to develop a computationally efficient statistical test for IBD mapping in biobank-scale cohorts. We used sparse linear algebra and random matrix algorithms to speed up the c

SUBMITTER: Chen H 

PROVIDER: S-EPMC10718418 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature