Dataset Information

Association between inflammation-based prognostic markers and mortality of non-cardiac surgery.

ABSTRACT:

Background

To evaluate the association between inflammation and nutrition-based biomarkers and postoperative outcomes after non-cardiac surgery.

Methods

Between January 2011 and June 2019, a total of 102,052 patients undergoing non-cardiac surgery were evaluated, with C-reactive protein (CRP), albumin, and complete blood count (CBC) measured within six months before surgery. We assessed their CRP-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and modified Glasgow Prognostic Score (mGPS). We determined the best cut-off values by using the receiver operating characteristic (ROC) curves. Patients were divided into high and low groups according to the estimated threshold, and we compared the one-year mortality.

Results

The one-year mortality of the entire sample was 4.2%. ROC analysis revealed areas under the curve of 0.796, 0.743, 0.670, and 0.708 for CAR, NLR, PLR, and mGPS, respectively. According to the estimated threshold, high CAR, NLR, PLR, and mGPS were associated with increased one-year mortality (1.7% vs. 11.7%, hazard ratio [HR]: 2.38, 95% CI [2.05, 2.76], P < 0.001 for CAR; 2.2% vs. 10.3%, HR: 1.81, 95% CI [1.62, 2.03], P < 0.001 for NLR; 2.6% vs. 10.5%, HR: 1.86, 95% CI [1.73, 2.01], P < 0.001 for PLR; and 2.3% vs. 16.3%, HR: 2.37, 95% CI [2.07, 2.72], P < 0.001 for mGPS).

Conclusions

Preoperative CAR, NRL, PLR, and mGPS were associated with postoperative mortality. Our findings may be helpful in predicting mortality after non-cardiac surgery.

SUBMITTER: Oh AR

PROVIDER: S-EPMC10718634 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Association between inflammation-based prognostic markers and mortality of non-cardiac surgery.

Oh Ah Ran AR Park Jungchan J Lee Jong-Hwan JH Yang Kwangmo K Ahn Joonghyun J Lee Seung-Hwa SH Lee Sangmin Maria SM

Korean journal of anesthesiology 20230224 6

<h4>Background</h4>To evaluate the association between inflammation and nutrition-based biomarkers and postoperative outcomes after non-cardiac surgery.<h4>Methods</h4>Between January 2011 and June 2019, a total of 102,052 patients undergoing non-cardiac surgery were evaluated, with C-reactive protein (CRP), albumin, and complete blood count (CBC) measured within six months before surgery. We assessed their CRP-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ...[more]

PMID: 36824044

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Dataset Information

Association between inflammation-based prognostic markers and mortality of non-cardiac surgery.

Background

Methods

Results

Conclusions

Publications

Association between inflammation-based prognostic markers and mortality of non-cardiac surgery.

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