Brain-wide correspondence of neuronal epigenomics and distant projections.

ABSTRACT: Single-cell analyses parse the brain's billions of neurons into thousands of 'cell-type' clusters residing in different brain structures¹. Many cell types mediate their functions through targeted long-distance projections allowing interactions between specific cell types. Here we used epi-retro-seq² to link single-cell epigenomes and cell types to long-distance projections for 33,034 neurons dissected from 32 different regions projecting to 24 different targets (225 source-to-target combinations) across the whole mouse brain. We highlight uses of these data for interrogating principles relating projection types to transcriptomics and epigenomics, and for addressing hypotheses about cell types and connections related to genetics. We provide an overall synthesis with 92

SUBMITTER: Zhou J 

PROVIDER: S-EPMC10719087 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature