Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults.

ABSTRACT: Over one million European children undergo computed tomography (CT) scans annually. Although moderate- to high-dose ionizing radiation exposure is an established risk factor for hematological malignancies, risks at CT examination dose levels remain uncertain. Here we followed up a multinational cohort (EPI-CT) of 948,174 individuals who underwent CT examinations before age 22 years in nine European countries. Radiation doses to the active bone marrow were estimated on the basis of body part scanned, patient characteristics, time period and inferred CT technical parameters. We found an association between cumulative dose and risk of all hematological malignancies, with an excess relative risk of 1.96 (95% confidence interval 1.10 to 3.12) per 100 mGy (790 cases). Similar estimates were obta

SUBMITTER: Bosch de Basea Gomez M 

PROVIDER: S-EPMC10719096 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature