Molecularly defined and spatially resolved cell atlas of the whole mouse brain.

ABSTRACT: In mammalian brains, millions to billions of cells form complex interaction networks to enable a wide range of functions. The enormous diversity and intricate organization of cells have impeded our understanding of the molecular and cellular basis of brain function. Recent advances in spatially resolved single-cell transcriptomics have enabled systematic mapping of the spatial organization of molecularly defined cell types in complex tissues^1-3, including several brain regions (for example, refs. ^1-11). However, a comprehensive cell atlas of the whole brain is still missing. Here we imaged a panel of more than 1,100 genes in approximately 10 million cells across the entire adult mouse brains using multiplexed error-robust fluorescence in situ hybridization¹²

SUBMITTER: Zhang M 

PROVIDER: S-EPMC10719103 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature