Evolution of neuronal cell classes and types in the vertebrate retina.

ABSTRACT: The basic plan of the retina is conserved across vertebrates, yet species differ profoundly in their visual needs¹. Retinal cell types may have evolved to accommodate these varied needs, but this has not been systematically studied. Here we generated and integrated single-cell transcriptomic atlases of the retina from 17 species: humans, two non-human primates, four rodents, three ungulates, opossum, ferret, tree shrew, a bird, a reptile, a teleost fish and a lamprey. We found high molecular conservation of the six retinal cell classes (photoreceptors, horizontal cells, bipolar cells, amacrine cells, retinal ganglion cells (RGCs) and Müller glia), with transcriptomic variation across species related to evolutionary distance. Major subclasses were also conserved, whereas variatio

SUBMITTER: Hahn J 

PROVIDER: S-EPMC10719112 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature