Protein intrinsically disordered regions have a non-random, modular architecture.

ABSTRACT:

Motivation

Protein sequences can be broadly categorized into two classes: those which adopt stable secondary structure and fold into a domain (i.e. globular proteins), and those that do not. The sequences belonging to this latter class are conformationally heterogeneous and are described as being intrinsically disordered. Decades of investigation into the structure and function of globular proteins has resulted in a suite of computational tools that enable their sub-classification by domain type, an approach that has revolutionized how we understand and predict protein functionality. Conversely, it is unknown if sequences of disordered protein regions are subject to broadly generalizable organizational principles that would enable their sub-classification.

Results

Here, we r

SUBMITTER: McConnell BS 

PROVIDER: S-EPMC10719218 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature