The association of serum choline concentrations with the risk of cancers: a community-based nested case-control study.

ABSTRACT: Few studies have been designed to investigate the effect of serum choline on the risk of incident cancer. This study aims to explore the association between serum choline and the risk of new-onset cancer. We conducted a case-control study, including 199 patients with incident cancer and 199 matched controls during a median of 3.9 years of follow-up, nested within the China Stroke Primary Prevention Trial. Cubic spline regression (RCS) and conditional logistic regression analysis was used to assess the association of serum choline and incident cancer risk. We observed a positive dose-response association between serum choline levels and the risk of overall (p for overall = 0.046) and digestive system cancer (p for overall = 0.039). Compared with patients with the lowest choline levels (Q1 g

SUBMITTER: Li W 

PROVIDER: S-EPMC10719238 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature