Mendelian randomization reveals association between retinal thickness and non-motor symptoms of Parkinson's disease.

ABSTRACT: Retinal thickness is related to Parkinson's disease (PD), but its association with the severity of PD is still unclear. We conducted a Mendelian randomized (MR) study to explore the association between retinal thickness and PD. For the two-sample MR analysis, the summary statistics obtained from genome-wide association studies on the thickness of Retinal nerve fiber layer (RNFL) and ganglion cell inner plexiform layer (GCIPL) were employed as exposure, while the summary statistics associated with PD were used as the outcome. The primary approach utilized was inverse variance weighted. To correct for multiple testing, the false discovery rate (FDR) was employed. For sensitivity analysis, an array of robust MR methods was utilized. We found genetically predicted significant association betwe

SUBMITTER: Zhou H 

PROVIDER: S-EPMC10719335 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature