Photoinduced copper-catalyzed C-N coupling with trifluoromethylated arenes.

ABSTRACT: Selective defluorinative functionalization of trifluoromethyl group (-CF₃) is an attractive synthetic route to the pharmaceutically privileged fluorine-containing moiety. Herein, we report a strategy based on photoexcited copper catalysis to activate the C-F bond of di- or trifluoromethylated arenes for divergent radical C-N coupling with carbazoles and aromatic amines. The use of different ligands can tune the reaction products diversity. A range of substituted, structurally diverse α,α-difluoromethylamines can be obtained from trifluoromethylated arenes via defluorinative C-N coupling with carbazoles, while an interesting double defluorinative C-N coupling is ready for difluoromethylated arenes. Based on this success, a carbazole-centered PNP ligand is designed to be an optima

SUBMITTER: Huang J 

PROVIDER: S-EPMC10719352 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature