A protein-protein interaction analysis tool for targeted cross-linking mass spectrometry.

ABSTRACT: Protein networking is critical to understanding the biological functions of proteins and the underlying mechanisms of disease. However, identifying physical protein-protein interactions (PPIs) can be challenging. To gain insights into target proteins that interact with a particular disease, we need to profile all the proteins involved in the disease beforehand. Although the cross-linking mass spectrometry (XL-MS) method is a representative approach to identify physical interactions between proteins, calculating theoretical mass values for application to targeted mass spectrometry can be difficult. To address this challenge, our research team developed PPIAT, a web application that integrates information on reviewed human proteins, protein-protein interactions, cross-linkers, enzymes, and m

SUBMITTER: Park J 

PROVIDER: S-EPMC10719354 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature