Molecular mapping of a core transcriptional signature of microglia-specific genes in schizophrenia.

ABSTRACT: Besides playing a central role in neuroinflammation, microglia regulate synaptic development and is involved in plasticity. Converging lines of evidence suggest that these different processes play a critical role in schizophrenia. Furthermore, previous studies reported altered transcription of microglia genes in schizophrenia, while microglia itself seems to be involved in the etiopathology of the disease. However, the regional specificity of these brain transcriptional abnormalities remains unclear. Moreover, it is unknown whether brain and peripheral expression of microglia genes are related. Thus, we investigated the expression of a pre-registered list of 10 genes from a core signature of human microglia both at brain and peripheral levels. We included 9 independent Gene Expression Omni

SUBMITTER: Fiorito AM 

PROVIDER: S-EPMC10719376 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature