Dose selection for biological enzyme replacement therapy indicated for inborn errors of metabolism.

ABSTRACT: This paper summarizes key features of the dose-finding strategies used in the development of 11 approved new molecular entities that are first-in-class enzyme replacement therapy (ERT), with a goal to gain insight into the dose exploration approaches to inform efficient dose-finding in future development of biological products for Inborn Errors of Metabolism (IEM). Dose exploration should preferably begin in in vitro studies, followed by testing multiple doses in an appropriate animal disease model, when available, which can provide important information for dose assessment in humans. Performing adequate dose-finding in early phase clinical studies in a well-defined study population, including pediatric subjects, is generally critical to inform dose selection for pivotal trials; alternativ

SUBMITTER: Hon YY 

PROVIDER: S-EPMC10719471 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature