CircRNA landscape in dorsal root ganglia from mice with collagen antibody-induced arthritis.

ABSTRACT: Circular RNAs are a novel class of RNA molecules that are covalently closed into a ring structure. They are an epigenetic regulatory mechanism, and their best-studied function is regulation of microRNA activity. As such circular RNAs may be involved in the switch from acute to chronic pain. They have previously been studied in the context of neuropathic pain models, but their importance in inflammation-induced chronic pain models is unexplored. Microarray analysis of dorsal root ganglia collected in the late phase of collagen antibody-induced arthritis (day 59) were used to elucidate the relevance of circular RNAs in the mechanical hypersensitivity caused by this model. 120 circular RNA genes were found to be significantly differentially regulated in female BALB/c mice with collagen antibo

SUBMITTER: Kurtovic Z 

PROVIDER: S-EPMC10719524 | biostudies-literature | 2023 Aug-Dec

REPOSITORIES: biostudies-literature