Serum neurofilament light concentrations are associated with cortical thinning in anorexia nervosa.

ABSTRACT:

Background

Anorexia nervosa (AN) is characterized by severe emaciation and drastic reductions of brain mass, but the underlying mechanisms remain unclear. The present study investigated the putative association between the serum-based protein markers of brain damage neurofilament light (NF-L), tau protein, and glial fibrillary acidic protein (GFAP) and cortical thinning in acute AN.

Methods

Blood samples and magnetic resonance imaging scans were obtained from 52 predominantly adolescent, female patients with AN before and after partial weight restoration (increase in body mass index >14%). The effect of marker levels before weight gain and change in marker levels on cortical thickness (CT) was modeled at each vertex of the cortical surface using linear mixed-effect models. T

SUBMITTER: Hellerhoff I 

PROVIDER: S-EPMC10719626 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature