A population-based twin study of the symptomatic diagnostic criteria for major depression that occur within versus outside of major depressive episodes.

ABSTRACT:

Background

Are genetic risk factors for current depressive symptoms good proxies for genetic risk factors for syndromal major depression (MD)?

Methods

In over 9000 twins from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders, the occurrence of all nine DSM symptomatic criteria for MD in the last year was assessed at personal interview and then grouped by their temporal co-occurrence. The DSM criteria which occurred outside (OUT) v. inside of (IN) MD episodes were then separated. We calculated tetrachoric correlations for OUT and IN depressive criteria in monozygotic (MZ) and dizygotic (DZ) pairs and fitted univariate and bivariate ACE twin models using OpenMx.

Results

The mean twin correlations (±95% CIs) for IN depressiv

SUBMITTER: Kendler KS 

PROVIDER: S-EPMC10719671 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature