Associations between acute and chronic lifetime stressors and psychosis-risk symptoms in individuals with 22q11.2 copy number variants.

ABSTRACT:

Background

The 22q11.2 deletion (22q11Del) is among the strongest known genetic risk factors for psychosis. Stress, a known risk factor for psychosis in the general population, has seldom been studied in 22q11Del. We investigated how lifetime stressors related to symptomatic outcomes in patients with 22q11Del. We also explored this association in individuals with 22q11.2 duplications (22q11Dup), which may be potentially protective against psychosis.

Method

One hundred individuals (46 with 22q11Del, 30 with 22q11Dup, and 24 healthy controls; M_age = 17.30 years±10.15) were included. Logistic models were used to examine cross-sectional associations between lifetime acute and chronic stressors (severity and count) and the presence (score ⩾3) of positive, negati

SUBMITTER: Modasi J 

PROVIDER: S-EPMC10719673 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature