Characterizing the clinical profile of mania without major depressive episodes: a systematic review and meta-analysis of factors associated with unipolar mania.

ABSTRACT:

Background

The diagnostic concept of unipolar mania (UM), i.e. the lifetime occurrence of mania without major depressive episodes, remains a topic of debate despite the evidence accumulated in the last few years. We carried out a systematic review and meta-analysis of observational studies testing factors associated with UM as compared to bipolar disorder with a manic-depressive course (md-BD).

Methods

Studies indexed up to July 2022 in main electronic databases were searched. Random-effects meta-analyses of the association between UM and relevant correlates yielded odds ratio (OR) or standardized mean difference (SMD), with 95% confidence intervals (CIs).

Results

Based on data from 21 studies, factors positively or negatively associated with UM, as compared to md-BD,

SUBMITTER: Bartoli F 

PROVIDER: S-EPMC10719688 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature