Dual anticancer and antibacterial activity of fluorescent naphthoimidazolium salts.

ABSTRACT: Cancer has emerged as a significant global health challenge, ranking as the second leading cause of death worldwide. Moreover, cancer patients frequently experience compromised immune systems, rendering them susceptible to bacterial infections. Combining anticancer and antibacterial properties in a single drug could lead to improved overall treatment outcomes and patient well-being. In this context, the present study focused on a series of hydrophilic naphthoimidazolium salts with donor groups (NI-R), aiming to create dual-functional agents with antibacterial and anticancer activities. Among these compounds, NI-TPA demonstrated notable antibacterial activity, particularly against drug-resistant bacteria, with MIC value of 7.8 μg mL^-1. Furthermore, NI-TPA exhibited the most poten

SUBMITTER: Tran DN 

PROVIDER: S-EPMC10719908 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature