Reprogramming tumour-associated macrophages to outcompete cancer cells.

ABSTRACT: In metazoan organisms, cell competition acts as a quality control mechanism to eliminate unfit cells in favour of their more robust neighbours^1,2. This mechanism has the potential to be maladapted, promoting the selection of aggressive cancer cells^3-6. Tumours are metabolically active and are populated by stroma cells^7,8, but how environmental factors affect cancer cell competition remains largely unknown. Here we show that tumour-associated macrophages (TAMs) can be dietarily or genetically reprogrammed to outcompete MYC-overexpressing cancer cells. In a mouse model of breast cancer, MYC overexpression resulted in an mTORC1-dependent 'winner' cancer cell state. A low-protein diet inhibited mTORC1 signalling in cancer cells and reduced tumour growth, owing

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10719927 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature