Fibroblast growth factor 13-mediated regulation of medium spiny neuron excitability and cocaine self-administration.

ABSTRACT: Cocaine use disorder (CUD) is a prevalent neuropsychiatric disorder with few existing treatments. Thus, there is an unmet need for the identification of new pharmacological targets for CUD. Previous studies using environmental enrichment versus isolation paradigms have found that the latter induces increased cocaine self-administration with correlative increases in the excitability of medium spiny neurons (MSN) of the nucleus accumbens shell (NAcSh). Expanding upon these findings, we sought in the present investigation to elucidate molecular determinants of these phenomena. To that end, we first employed a secondary transcriptomic analysis and found that cocaine self-administration differentially regulates mRNA for fibroblast growth factor 13 (FGF13), which codes for a prominent auxiliary

SUBMITTER: Dvorak NM 

PROVIDER: S-EPMC10720079 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature