Interaction between childhood trauma experience and TPH2 rs7305115 gene polymorphism in brain gray matter volume.

ABSTRACT:

Background

Childhood trauma is one of the most extensively studied and well-supported environmental risk factors for the development of mental health problems. The human tryptophan hydroxylase 2 (TPH2) gene is one of the most promising candidate genes in numerous psychiatric disorders. However, it is now widely acknowledged that neither genetic variation nor environmental exposure alone can fully explain all the phenotypic variance observed in psychiatric disorders. Therefore, it is necessary to consider the interaction between the two factors in psychiatric research.

Methods

We enrolled a sizable nonclinical cohort of 786 young, healthy adults who underwent structural MRI scans and completed genotyping, the Childhood Trauma Questionnaire (CTQ) and behavioural scores. We ide

SUBMITTER: Li W 

PROVIDER: S-EPMC10720107 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature