IL-17A promotes the progression of Alzheimer's disease in APP/PS1 mice.

ABSTRACT:

Background

Alzheimer's disease (AD), which is the most common cause of dementia in elderly individuals, is a progressive neurodegenerative disorder. Neuroinflammation, which is an immune response that is activated by glial cells in the central nervous system, plays an important role in neurodegenerative diseases. Many studies have shown that interleukin-17A (IL-17A) plays an important role in AD, but research on the pathological effects of IL-17A on AD is limited.

Methods

We report the effect of IL-17A on AD progression in APPswe/PS1dE9 (APP/PS1) mice, which are the most widely used AD model mice. The BV2 cell line, which is a microglial cell line derived from C57/BL6 mice, was used to establish a cell model to verify the role of IL-17A in neuroinflammation at the cellular l

SUBMITTER: Cao M 

PROVIDER: S-EPMC10720112 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature