Plasmodium knowlesi in pig-tailed macaques: a potential new model for malaria vaccine research.

ABSTRACT:

Background

Plasmodium knowlesi is an established experimental model for basic and pre-clinical malaria vaccine research. Historically, rhesus macaques have been the most common host for malaria vaccine studies with P. knowlesi parasites. However, rhesus are not natural hosts for P. knowlesi, and there is interest in identifying alternative hosts for vaccine research. The study team previously reported that pig-tailed macaques (PTM), a natural host for P. knowlesi, could be challenged with cryopreserved P. knowlesi sporozoites (PkSPZ), with time to blood stage infection equivalent to in rhesus. Here, additional exploratory studies were performed to evaluate PTM as potential hosts for malaria vaccine studies. The aim was to further characterize the parasitological and veterinary heal

SUBMITTER: Shears MJ 

PROVIDER: S-EPMC10720125 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature