Efficacy and mechanism of Shenqi Compound in inhibiting diabetic vascular calcification.

ABSTRACT:

Background

Shenqi Compound (SQC) has been used in clinic for several decades in the prevention and treatment of diabetes and its complications. But this is merely a heritage of experience. The primary aim of this study is to scientifically validate the therapeutic effects of SQC on diabetic vascular calcification (DVC) in an animal model and, simultaneously, uncover its potential underlying mechanisms.

Method

Spontaneous diabetic rat- Goto Kakizaki (GK) rats were selected for rat modeling. We meticulously designed three distinct groups: a control group, a model group, and an SQC treatment group to rigorously evaluate the influence of SQC. Utilizing a comprehensive approach that encompassed methods such as pathological staining, western blot analysis, qRT-PCR, and RNA sequenc

SUBMITTER: Yang C 

PROVIDER: S-EPMC10720156 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature