Mesenchymal stem cells overexpressing interleukin-10 prevent allergic airway inflammation.

ABSTRACT:

Backgrounds

Allergic airway inflammation is prevalent worldwide and imposes a considerable burden on both society and affected individuals. This study aimed to investigate the therapeutic advantages of mesenchymal stem cells (MSCs) overexpressed interleukin-10 (IL-10) for the treatment of allergic airway inflammation, as both IL-10 and MSCs possess immunosuppressive properties.

Methods

Induced pluripotent stem cell (iPSC)-derived MSCs were engineered to overexpress IL-10 via lentiviral transfection (designated as IL-10-MSCs). MSCs and IL-10-MSCs were administered intravenously to mice with allergic inflammation induced by ovalbumin (OVA), and the features of allergic inflammation including inflammatory cell infiltration, Th cells in the lungs, and T helper 2 cell (Th2) cytok

SUBMITTER: Kuang PP 

PROVIDER: S-EPMC10720159 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature