Cardiac structure discontinuities revealed by ex-vivo microstructural characterization. A focus on the basal inferoseptal left ventricle region.

ABSTRACT:

Background

While the microstructure of the left ventricle (LV) has been largely described, only a few studies investigated the right ventricular insertion point (RVIP). It was accepted that the aggregate cardiomyocytes organization was much more complex due to the intersection of the ventricular cavities but a precise structural characterization in the human heart was lacking even if clinical phenotypes related to right ventricular wall stress or arrhythmia were observed in this region.

Methods

MRI-derived anatomical imaging (150 µm³) and diffusion tensor imaging (600 µm³) were performed in large mammalian whole hearts (human: N = 5, sheep: N = 5). Fractional anisotropy, aggregate cardiomyocytes orientations and tractography were compared within both sp

SUBMITTER: Cabanis P 

PROVIDER: S-EPMC10720182 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature