Comprehensive prognostic and immune analysis of a glycosylation related risk model in pancreatic cancer.

ABSTRACT:

Background

Pancreatic cancer (PC) is a malignant tumor with extremely poor prognosis, exhibiting resistance to chemotherapy and immunotherapy. Nowadays, it is ranked as the third leading cause of cancer-related mortality. Glycation is a common epigenetic modification that occurs during the tumor transformation. Many studies have demonstrated a strong correlation between glycation modification and tumor progression. However, the expression status of glycosylation-related genes (GRGs) in PC and their potential roles in PC microenvironment have not been extensively investigated.

Method

We systematically integrated RNA sequencing data and clinicopathological parameters of PC patients from TCGA and GTEx databases. A GRGs risk model based on glycosylation related genes was constru

SUBMITTER: Liu X 

PROVIDER: S-EPMC10720206 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature