Triglyceride-glucose index is associated with a higher risk of stroke in a hypertensive population.

ABSTRACT:

Background

This study aimed to evaluate the association of triglyceride-glucose (TyG) index, an insulin resistance surrogate biomarker, with first stroke in a hypertensive population and to explore potential influencing factors.

Methods

This study, a cohort study among a rural Chinese hypertensive population, utilized data from the China Stroke Primary Prevention Trial (CSPPT). The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Multivariate analysis using Cox proportional hazards models was conducted.

Results

A total of 7569 hypertensive patients were included in this study. When TyG index was assessed as quartiles, compared with the reference group (Quartile 1), the hazard ratio of stroke was 1.04 in Quartile 2, 1.43 in Qua

SUBMITTER: Zhang N 

PROVIDER: S-EPMC10720217 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature