Transcriptome-wide N⁶-methyladenosine methylation profile of atherosclerosis in mice.

ABSTRACT:

Background

Atherosclerosis (AS) is a critical pathological event during the progression of cardiovascular diseases. It exhibits fibrofatty lesions on the arterial wall and lacks effective treatment. N⁶-methyladenosine (m⁶A) is the most common modification of eukaryotic RNA and plays an important role in regulating the development and progression of cardiovascular diseases. However, the role of m⁶A modification in AS remains largely unknown. Therefore, in this study, we explored the transcriptome distribution of m⁶A modification in AS and its potential mechanism.

Methods

Methylation Quantification Kit was used to detect the global m⁶A levels in the aorta of AS mice. Western blot was used to analyze the protein level of me

SUBMITTER: Zheng X 

PROVIDER: S-EPMC10720251 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature