Oxidized Phospholipid oxPAPC Alters Regulatory T-Cell Differentiation and Decreases Their Protective Function in Atherosclerosis in Mice.

ABSTRACT:

Background

Regulatory T cells (T_regs) are protective in atherosclerosis but reduced during disease progression due to cell death and loss of stability. However, the mechanisms of T_reg dysfunction remain unknown. Oxidized phospholipids are abundant in atherosclerosis and can activate innate immune cells, but little is known regarding their impact on T cells. Given T_reg loss during atherosclerosis progression and oxidized phospholipid levels in the plaque microenvironment, we investigated whether oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (oxPAPC), an oxidized phospholipid associated with atherosclerotic plaques, alters T_reg differentiation and function.

Methods

CD4⁺ T cells were polarized to T_reg

SUBMITTER: Appleton BD 

PROVIDER: S-EPMC10720352 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature