Non-therapeutic plasma levels in individuals utilizing curcumin supplements in daily life.

ABSTRACT:

Introduction

The spice curcumin and its metabolites are widely used by cancer patients but have not shown proven health benefits in clinical studies, likely due to low plasma concentrations after oral intake. However, public interest in curcumin continues to grow, and companies claim enhanced absorption in their formulations. This study aims to determine if daily oral intake of curcumin leads to sufficient plasma concentrations for health effects. The study was registered in the Dutch Clinical Trial Register with ID NL5931.

Methods

We used a validated HPLC-MS/MS method to measure curcumin and its metabolites in 47 individuals using their own curcumin formulations. Questionnaires assessed other supplement and medication use. Plasma samples were collected before and 1.5 h afte

SUBMITTER: Kroon MAGM 

PROVIDER: S-EPMC10720437 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature