Jumbo phages are active against extensively drug-resistant eyedrop-associated Pseudomonas aeruginosa infections.

ABSTRACT: Antibiotic-resistant bacteria present an emerging challenge to human health. Their prevalence has been increasing across the globe due in part to the liberal use of antibiotics that has pressured them to develop resistance. Those bacteria that acquire mobile genetic elements are especially concerning because those plasmids may be shared readily with other microbes that can then also become antibiotic resistant. Serious infections have recently been related to the contamination of preservative-free eyedrops with extensively drug-resistant (XDR) isolates of Pseudomonas aeruginosa, already resulting in three deaths. These drug-resistant isolates cannot be managed with most conventional antibiotics. We sought to identify alternatives to conventional antibiotics for the lysis of these XD

SUBMITTER: Cobian Guemes AG 

PROVIDER: S-EPMC10720484 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature