Plasmid genomic epidemiology of bla_KPC carbapenemase-producing Enterobacterales in Canada, 2010-2021.

ABSTRACT: Carbapenems are considered last-resort antibiotics for the treatment of infections caused by multidrug-resistant Enterobacterales, but carbapenem resistance due to acquisition of carbapenemase genes is a growing threat that has been reported worldwide. Klebsiella pneumoniae carbapenemase (bla_KPC) is the most common type of carbapenemase in Canada and elsewhere; it can hydrolyze penicillins, cephalosporins, aztreonam, and carbapenems and is frequently found on mobile plasmids in the Tn4401 transposon. This means that alongside clonal expansion, bla_KPC can disseminate through plasmid- and transposon-mediated horizontal gene transfer. We applied whole genome sequencing to characterize the molecular epidemiology of 829 bla_KPC

SUBMITTER: Lerminiaux N 

PROVIDER: S-EPMC10720558 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature