Isavuconazole use and TDM in real-world pediatric practice.

ABSTRACT: Isavuconazole (ISA) is approved for treating invasive aspergillosis and mucormycosis in adults, but its use in children remains off-label. We report on the use of ISA in real-world pediatric practice with 15 patients receiving ISA for treatment of invasive fungal infections. Therapeutic drug monitoring (TDM) was performed in all patients, with 52/111 (46.8%) C_trough determinations out of range, thus supporting the need for TDM in children, especially those receiving extracorporeal membrane oxygenation (ECMO).

SUBMITTER: Fernandez Ledesma B 

PROVIDER: S-EPMC10720574 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature