Individual and combined association between nutritional trace metals and the risk of preterm birth in a recurrent pregnancy loss cohort.

ABSTRACT:

Background

Recurrent pregnancy loss (RPL) was associated with an elevated risk of pregnancy complications, particularly preterm birth (PTB). However, the risk factors associated with PTB in RPL remained unclear. Emerging evidence indicated that maternal exposure to metals played a crucial role in the development of PTB. The objective of our study was to investigate the individual and combined associations of nutritional trace metals (NTMs) during pregnancy with PTB in RPL.

Methods

Using data from a recurrent pregnancy loss cohort (n = 459), propensity score matching (1:3) was performed to control for covariates. Multiple logistic regression and multiple linear regression were employed to identify the individual effects, while elastic-net regularization (ENET) and Baye

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10720726 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature