Association of Circulating Antiretinal Antibodies With Clinical Outcomes in Retinitis Pigmentosa.

ABSTRACT:

Purpose

To determine if circulating antiretinal antibodies (ARAs) differ between patients affected by retinitis pigmentosa (RP) and control participants and to assess whether ARAs are associated with clinical outcomes in patients with RP.

Methods

Cross-sectional study involving a group of patients clinically diagnosed with RP and a control group of healthy participants. Serum autoantibodies against enolase, heat shock protein 70 (HSP70), and carbonic anhydrase II (CAII) were tested in all participants using Jess capillary Western blot. We compared ARA prevalence between the RP and control groups and investigated the association of serum ARA positivity with macular edema and vitreomacular disorders in patients affected by RP.

Results

Thirty-six patients affected by RP

SUBMITTER: Bianco L 

PROVIDER: S-EPMC10720755 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature