Finding the minimum number of retrieved lymph nodes in Node-negative colorectal cancer using Real-world Data and the SEER database.

ABSTRACT:

Background

Current clinical guidelines recommend the removal of at least 12 lymph nodes (LNs) in resectable colorectal cancer (CRC). With advancements in lymphadenectomy technologies, the number of retrieved lymph nodes (rLNs) has markedly increased. This study aimed to investigate the lowest number of rLNs in node-negative patients.

Materials and methods

A total of 1103 N0 and 208 N1a stage patients were enrolled in our cohort, while 8503 N0 and 1276 N1a patients from the Surveillance, Epidemiology, and End Results CRC database were included. Propensity score matching and multivariate Cox regression analyses were performed to mitigate the influence of selection bias and control for potential confounding variables.

Results

The median number of rLNs in N0 patients incr

SUBMITTER: Qiao Y 

PROVIDER: S-EPMC10720778 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature