Isolation and genome sequencing of cytomegaloviruses from Natal multimammate mice (<i>Mastomys natalensis</i>).

ABSTRACT: Distinct cytomegaloviruses (CMVs) are widely distributed across their mammalian hosts in a highly host species-restricted pattern. To date, evidence demonstrating this has been limited largely to PCR-based approaches targeting small, conserved genomic regions, and only a few complete genomes of isolated viruses representing distinct CMV species have been sequenced. We have now combined direct isolation of infectious viruses from tissues with complete genome sequencing to provide a view of CMV diversity in a wild animal population. We targeted Natal multimammate mice (Mastomys natalensis), which are common in sub-Saharan Africa, are known to carry a variety of zoonotic pathogens, and are regarded as the primary source of Lassa virus (LASV) spillover into humans. Using transformed epi

SUBMITTER: Hansen F 

PROVIDER: S-EPMC10721045 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature