Frequentist model averaging for analysis of dose-response in epidemiologic studies with complex exposure uncertainty.

ABSTRACT: In epidemiologic studies, association estimates of an exposure with disease outcomes are often biased when the uncertainties of exposure are ignored. Consequently, corresponding confidence intervals (CIs) will not have correct coverage. This issue is particularly problematic when exposures must be reconstructed from physical measurements, for example, for environmental or occupational radiation doses that were received by a study population for which radiation doses cannot be measured directly. To incorporate complex uncertainties in reconstructed exposures, the two-dimensional Monte Carlo (2DMC) dose estimation method has been proposed and used in various dose reconstruction efforts. The 2DMC method generates multiple exposure realizations from dosimetry models that incorporate various so

SUBMITTER: Kwon D 

PROVIDER: S-EPMC10721059 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature