A Mendelian randomization study on the causal association of circulating cytokines with colorectal cancer.

ABSTRACT:

Background

Circulating cytokines have been associated with colorectal cancer (CRC). However, their causal correlation remains undetermined. This investigation uses genetic data to evaluate the mechanism that links circulating cytokines and CRC via Mendelian Randomization (MR).

Methods

A two-sample MR evaluation was carried out to investigate the mechanism associating circulating cytokines and CRC in individuals of European ancestry. The Genome-wide association studies statistics, which are publically accessible, were used. Eligible instrumental SNPs that were significantly related to the circulating cytokines were selected. Multiple MR analysis approaches were carried out, including Simple Mode, inverse variance weighted (IVW), MR-Egger, Weighted Mode, Weighted Median, and M

SUBMITTER: Kong Y 

PROVIDER: S-EPMC10721084 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature