Disease phenotype of classical sheep scrapie is changed upon experimental passage through white-tailed deer.

ABSTRACT: Prion agents occur in strains that are encoded by the structure of the misfolded prion protein (PrPSc). Prion strains can influence disease phenotype and the potential for interspecies transmission. Little is known about the potential transmission of prions between sheep and deer. Previously, the classical US scrapie isolate (No.13-7) had a 100% attack rate in white-tailed deer after oronasal challenge. The purpose of this study was to test the susceptibility of sheep to challenge with the scrapie agent after passage through white-tailed deer (WTD scrapie). Lambs of various prion protein genotypes were oronasally challenged with WTD scrapie. Sheep were euthanized and necropsied upon development of clinical signs or at the end of the experiment (72 months post-inoculation). Enzyme immunoass

SUBMITTER: Kokemuller RD 

PROVIDER: S-EPMC10721168 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature